Blood pressure predicted effector genes
Blood pressure predicted effector genes
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Method
Genes were prioritized at blood pressure-associated loci by combining several types of evidence:
Obesity predicted effector genes
Obesity predicted effector genes
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Method
Variants located in obesity-associated GWAS loci were tested for cell type specific or cross-tissue enhancer modulating properties using a massively parallel reporter assay.
Emphysema and airway phenotypes in COPD 2015 GWAS: trans-ancestry
Publications
A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.
Cho MH, et al.
J Respir Crit Care Med. 2015 Sep 1;192(5):559-69. doi: 10.1164/rccm.201501-0148OC.
PMID: 26030696
Idiopathic pulmonary fibrosis survival 2022 GWAS: European ancestry
Summary statistics are available for download from the International IPF Genetics Consortium.
Publications
PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
Oldham JM, et al.
Submitted for publication, 2022.
bioRxiv preprint
Lung function in idiopathic pulmonary fibrosis 2022 GWAS: European ancestry
Summary statistics are available for download from the International IPF Genetics Consortium.
Publications
Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study.
Allen RJ, et al.
Lancet Respir Med. 2022 Aug 16:S2213-2600(22)00251-X. doi:10.1016/S2213-2600(22)00251-X.
PMID: 35985358
Idiopathic pulmonary fibrosis 2022 GWAS: European ancestry
Summary statistics are available for download from the International IPF Genetics Consortium.
Publications
Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.
Allen RJ, et al.
Thorax. 2022 Aug;77(8):829-833. doi: 10.1136/thoraxjnl-2021-218577.
PMID: 35688625
Polycystic ovary syndrome 2022 GWAS: European ancestry
Summary statistics are available for download from the GWAS Catalog.
Publications
Leveraging Northern European population history: novel low-frequency variants for polycystic ovary syndrome.
Tyrmi JS, et al.
Hum Reprod. 2022 Jan 28;37(2):352-365. doi: 10.1093/humrep/deab250.
PMID: 34791234
Glomerular filtration rate (eGFRcrea) 2022 GWAS: trans-ancestry
The authors have made the summary statistics available for download.
Publications
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.
Liu H, et al.
Nat Genet. 2022 Jul;54(7):950-962. doi: 10.1038/s41588-022-01097-w.
PMID: 35710981
Insomnia 2022 GWAS: males, European ancestry
The authors have made the summary statistics from the UK Biobank samples (minus 23andMe) available for download.
Publications
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.
Watanabe K, et al.
Nat Genet. 2022 Aug;54(8):1125-1132. doi: 10.1038/s41588-022-01124-w.
PMID: 35835914
Insomnia 2022 GWAS: females, European ancestry
The authors have made the summary statistics from the UK Biobank samples (minus 23andMe) available for download.
Publications
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.
Watanabe K, et al.
Nat Genet. 2022 Aug;54(8):1125-1132. doi: 10.1038/s41588-022-01124-w.
PMID: 35835914