Pancreatic cell type-specific T2D predicted effector genes
Pancreatic cell type-specific T2D effector gene predictions
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Method
Single-cell RNA-seq, single-cell ATAC-seq, and high-resolution Hi-C were applied to pancreatic islets and sorted pancreatic acinar, alpha, and beta cells in order to discover cell type-specific gene regulation and to map variant-to-gene-by-cell type relationships for sentinel SNPs significantly associa
AMP T2D-GENES quantitative trait exome sequence analysis: South Asian ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: Hispanic ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: European ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: East Asian ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: African American ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMD progression 2018 GWAS
Summary statistics are available for download from the GWAS Catalog.
Publications
Genome-wide analysis of disease progression in age-related macular degeneration.
Yan Q, et al.
Hum Mol Genet. 2018 Mar 1;27(5):929-940. doi: 10.1093/hmg/ddy002.
PMID: 29346644
Diabetic nephropathy 2018 GWAS: East Asian ancestry
Summary statistics are available for download from the GWAS Catalog.
Publications
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Taira M, et al.
PLoS One. 2018 Dec 19;13(12):e0208654. doi: 10.1371/journal.pone.0208654.
PMID: 30566433
FinnDiane 2021 Coronary artery disease in type 1 diabetes GWAS: European ancestry
Summary statistics are available for download from the GRASP website.
Publications
Genome-wide association study on coronary artery disease in type 1 diabetes suggests beta-defensin 127 as a risk locus.
Antikainen AAV, et al.
Cardiovasc Res. 2021 Jan 21;117(2):600-612. doi: 10.1093/cvr/cvaa045.
PMID: 32077919
Rheumatoid arthritis 2012 ImmunoChip: European ancestry
Summary statistics are available for download from the GWAS Catalog.
Publications
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Eyre S, et al.
Nat Genet. 2012 Dec;44(12):1336-40. doi: 10.1038/ng.2462.
PMID: 23143596