Download GWAS summary statistics from studies on stroke and related traits | Download GWAS summary statistics from studies incorporated into the CDKP |
View downloads across all diseases and traits on the Association to Function Knowledge Portal Downloads page.
GWAS summary statistics from studies on stroke and related traits
Datasets listed in this table are not integrated into the CDKP. The table is ordered by publication date in reverse chronological order.
| Publication | Download files | README file |
|---|---|---|
| Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Malik R, et al. Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. PMID:29531354 | Download available here | |
| Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. Lubitz SA, et al. Stroke. 2017 Jun;48(6):1451-1456. doi: 10.1161/STROKEAHA.116.016198. PMID:28468926 | Information for download | |
| Genetic variation at 16q24.2 is associated with small vessel stroke Traylor M, et al. Ann Neurol. 2017 Mar;81(3):383-394. doi: 10.1002/ana.24840. PMID:27997041 | 27997041.Traylor.2017.tar.gz (299MB) | README |
| Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC). Lancet Neurol. 2016 Jun;15(7):695-707. doi: 10.1016/S1474-4422(16)00102-2. PMID:27068588 | Information for download | |
| Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Malik R, et al. Neurology. 2016 Mar 29;86(13):1217-26. doi: 10.1212/WNL.0000000000002528. PMID:26935894 | 4818561.Malik.2016.zip (1.3GB) | README |
| Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Traylor M, et al. Neurology. 2016 Jan 12;86(2):146-53. doi: 10.1212/WNL.0000000000002263. PMID:26674333 | 26674333.Traylor.2016.txt.gz (101MB) | README |
| Multi-ethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Verhaaren BF, et al. Circ Cardiovasc Genet. 2015 Apr;8(2):398-409. doi: 10.1161/CIRCGENETICS.114.000858. PMID:25663218 | Information for download | |
| Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Kilarski LL, et al. Neurology. 2014 Aug 19;83(8):678-85. doi: 10.1212/WNL.0000000000000707. PMID:25031287 | Information for download | |
| A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. Traylor M, et al. PLoS Genet. 2014 Jul 31;10(7):e1004469. doi: 10.1371/journal.pgen.1004469. PMID:25078452 | Information for download | |
| Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Traylor M, et al. Lancet Neurol. 2012 Nov;11(11):951-62. doi: 10.1016/S1474-4422(12)70234-X. PMID:23041239 | 3490334.Traylor.2012.zip (307MB) | README |
| Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Holliday EG, et al. Nat Genet. 2012 Oct;44(10):1147-51. doi: 10.1038/ng.2397. PMID:22941190 | Information for download | |
| Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke International Stroke Genetics Consortium, et al. Nat Genet. 2012 Feb 5;44(3):328-33. doi: 10.1038/ng.1081. PMID:22306652 | Information for download | |
| Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Fornage M, et al. Ann Neurol. 2011 Jun;69(6):928-39. doi: 10.1002/ana.22403. PMID:21681796 | Information for download (More information at the CHARGE Consortium website) |
GWAS summary statistics from studies incorporated into the CDKP
The table is ordered by publication date in reverse chronological order.
| Dataset name in CDKP | Publication | Phenotypes | Download links |
|---|---|---|---|
| Ischemic stroke 2024 GWAS: European ancestry | Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke. Cárcel-Márquez J, et al. Stroke. 2024 Oct;55(10):2462-2471. doi: 10.1161/STROKEAHA.124.047833. PMID: 39315829 | Ischemic stroke and sub-types | Summary statistics README |
| Recurrent stroke 2024 GWAS: European ancestry | Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis. Aldridge CM, et al. Front. Stroke, 21 February 2024, Volume 3 - 2024, https://doi.org/10.3389/fstro.2024.1338636 | Recurrent stroke | Summary statistics |
| Post-stroke motor recovery 2023 GWAS: trans-ancestry | Post Stroke Motor Recovery Genome Wide Association Study: A Domain-Specific Approach. Aldridge CM, et al. Neurology. 2023 Oct 9:10.1212/WNL.0000000000207716. doi: 10.1212/WNL.0000000000207716. PMID: 37813584 | Stroke recovery | |
| ISGC early-onset ischemic stroke 2022 GWAS | Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke. Jaworek T, et al. Neurology. 2022 Aug 31;99(16):e1738-e1754. doi: 10.1212/WNL.0000000000201006. PMID:36240095 | Stroke | Trans-ancestry results: Early-onset ischemic stroke | TOAST cardio-aortic embolism | TOAST large artery atherosclerosis | TOAST small artery occlusion | TOAST other determined | TOAST other undetermined European ancestry results: Early-onset ischemic stroke | TOAST cardio-aortic embolism | TOAST large artery atherosclerosis | TOAST small artery occlusion | TOAST other determined | TOAST other undetermined |
| Lacunar stroke 2021 GWAS: trans-ancestry; Lacunar stroke 2021 GWAS: European ancestry | Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies. Traylor M, et al. Lancet Neurol. 2021. May;20(5):351-361. doi: 10.1016/S1474-4422(21)00031-4. PMID:33773637 | Stroke | Download Transethnic summary statistics |
| Stroke 2020 GWAS: African American ancestry | Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. Keene KL, Hyacinth HI, et al. Stroke. 2020 Aug;51(8):2454-2463. doi: 10.1161/STROKEAHA.120.029123.. PMID:32693751 | Stroke | |
| Cerebral small vessel disease MRI markers 2020 GWAS: European ancestry | Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants. Persyn E, et al. Nat Commun. 2020 May 1;11(1):2175. doi: 10.1038/s41467-020-15932-3. PMID:32358547 | Cerebrovascular MRI traits | |
| Brain microbleeds GWAS | Association of common genetic variants with brain microbleeds: A genome-wide association study. Knol MJ et al. Neurology. 2020 Dec 15;95(24):e3331-e3343. doi: 10.1212/WNL.0000000000010852. PMID:32913026 | Brain microbleeds | Brain microbleeds, any, excluding dementia and stroke cases Brain microbleeds, mixed or strictly deep Brain microbleeds, mixed or strictly deep, excluding dementia and stroke cases Brain microbleeds, strictly lobar Brain microbleeds, strictly lobar, excluding dementia and stroke cases |
| Intracranial aneurysm GWAS | Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Bakker MK, et al. Nat Genet. 2020 Dec;52(12):1303-1313. doi: 10.1038/s41588-020-00725-7. PMID:33199917 | Aneurysm | |
| Cerebral Small Vessel Disease Multi-Trait Analysis of GWAS | Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Chung J, et al. Brain. 2019 Oct 1;142(10):3176-3189. doi: 10.1093/brain/awz233. PMID:31430377 | Stroke | Intracerebral hemorrhage or small vessel ischemic stroke summary statistics Lobar intracerebral hemorrhage or small vessel ischemic stroke summary statistics Non-lobar intracerebral hemorrhage or small vessel ischemic stroke summary statistics |
| GISCOME ischemic stroke outcome GWAS | Genome-wide Association Meta-Analysis of Functional Outcome After Ischemic Stroke. Söderholm M, et al. Neurology. 2019 Mar 19;92(12):e1271-e1283. doi: 10.1212/WNL.0000000000007138. PMID:30796134 | Ischemic stroke outcome | mRS 0-1 vs 2-6 at 3 months adj stroke severity mRS 0-2 vs 3-6 at 3 months adj stroke severity |
| Cerebral WMHV GWAS 2019 | Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226). Traylor M, et al. Neurology. 2019 Jan 18. pii: 10.1212/WNL.0000000000006952. doi: 10.1212/WNL.0000000000006952. PMID:30659137 | MRI Traits | Summary statistics | README |
| SiGN and NINDS 2016 stroke GWAS | Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. NINDS Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC). Lancet Neurol. 2016 Feb;15(2):174-184. doi: 10.1016/S1474-4422(15)00338-5. PMID:26708676 | Stroke | Summary statistics (50 GB) |
| ICH GWAS | Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage. Woo D, et al. Am J Hum Genet. 2014 Apr 3;94(4):511-21. doi: 10.1016/j.ajhg.2014.02.012. PMID:24656865 | Hemorrhagic stroke | Summary statistics (350MB) | README |