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test content
Predicted effector genes-mccarthy
These predictions synthesize multiple kinds of biological evidence to classify genes that are most likely to have direct roles in T2D risk and may represent potential drug targets. The “Combined prediction” column contains the classification of each gene’s potential to be causal based on the evidence contained in the table, as determined by Anubha Mahajan and Mark McCarthy. The classifications for potential T2D effectors are "Causal", "Strong", "Moderate", "Possible", and "Weak".
EGL method - richards
The Effector Index (Ei) algorithm calculates the probability of causality for each gene at a locus that harbors genome-wide significant SNVs for a disease or trait.
Full documentation is available in:
UK Biobank snoring GWAS adjusted for BMI
Dataset
Summary statistics are available for download at the GWAS Catalog.
Publications
Insights Into the Aetiology of Snoring From Observational and Genetic Investigations in the UK Biobank.
Campos AI, et al.
Nat Commun 2020 Feb 14;11(1):817. doi: 10.1038/s41467-020-14625-1.
PMID:32060260
IPF GWAS
Dataset
Download summary statistics here.
Publication
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Allen RJ, et al.
Am J Respir Crit Care Med 2020 Mar 1;201(5):564-574. doi: 10.1164/rccm.201905-1017OC.
PMID:31710517
UK Biobank snoring GWAS
Dataset
Summary statistics are available for download at the GWAS Catalog.
Publications
Insights Into the Aetiology of Snoring From Observational and Genetic Investigations in the UK Biobank.
Campos AI, et al.
Nat Commun 2020 Feb 14;11(1):817. doi: 10.1038/s41467-020-14625-1.
PMID:32060260
UK Biobank relative amplitude GWAS
Dataset
Publications
Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association With Mood Instability.
Ferguson A, et al.
EBioMedicine 2018 Sep;35:279-287. doi: 10.1016/j.ebiom.2018.08.004.
PMID:30120083
UK Biobank fat distribution GWAS
Dataset
Summary statistic files are available for download from the GIANT consortium website.
Publications
Genome-wide Association Study of Body Fat Distribution Identifies Adiposity Loci and Sex-Specific Genetic Effects.
Rask-Andersen M, et al.
Nat Commun 2019 Jan 21;10(1):339. doi: 10.1038/s41467-018-08000-4.
PMID:30664634
T2D in Africa GWAS
Dataset
Summary statistics are available for download at the GWAS Catalog.
Publications
Genome-wide Association Study of Type 2 Diabetes in Africa.
Chen J, et al.
Diabetologia. 2019 Jul;62(7):1204-1211. doi: 10.1007/s00125-019-4880-7.
PMID:31049640