Genes & Health cardiometabolic trait 2022 GWAS: South Asian ancestry
Summary statistics are available for download from the Genes & Health website.
Right heart 2022 GWAS: European ancestry
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Publications
Genetic analysis of right heart structure and function in 40,000 people.
Pirruccello JP, et al.
Nat Genet. 2022 Jun;54(6):792-803. doi:10.1038/s41588-022-01090-3.
PMID: 35697867
Genetic Loci Clustering 2022 Research Method
View a video from Hyungkyung Kim explaining how to navigate the Genetic Loci Clustering interfaces:
Research methods
I) Pipeline for input matrix for clustering
Pancreatic cell type-specific T2D predicted effector genes
Pancreatic cell type-specific T2D effector gene predictions
View predictions for:
Method
Single-cell RNA-seq, single-cell ATAC-seq, and high-resolution Hi-C were applied to pancreatic islets and sorted pancreatic acinar, alpha, and beta cells in order to discover cell type-specific gene regulation and to map variant-to-gene-by-cell type relationships for sentinel SNPs significantly associa
AMP T2D-GENES quantitative trait exome sequence analysis: South Asian ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: Hispanic ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: European ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: East Asian ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2
AMP T2D-GENES quantitative trait exome sequence analysis: African American ancestry
Publications
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.
Dornbos P, et al.
Nat Genet. 2022 Oct 24. doi: 10.1038/s41588-022-01200-1.
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Flannick J, et al.
Nature. 2019 May 22. doi: 10.1038/s41586-019-1231-2