Estimated glomerular filtration rate (eGFRcrea) predicted effector genes

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• Estimated glomerular filtration rate (serum creatinine)

Method

This study integrated results from 8 methods to prioritize putative kidney function effector genes at loci genetically associated with eGFRcrea.

Cardiometabolic trait predicted effector genes

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• Cardiometabolic traits

Method

Candidate causal genes for cardiometabolic traits were predicted by integration of genetic association results, expression and splicing quantitative trait loci (eQTLs and sQTLs), transcriptional regulation by physiological and pharmacological cardiometabolic regulators, and protein-protein interaction

Type 1 diabetes predicted effector genes

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• Type 1 diabetes

Method

These predictions synthesize genetic, perturbational, and regulatory evidence to categorize potential T1D effector genes by the strength of their supporting evidence.

Reference:

Onengut-Gumuscu S and Rich SS. Unpublished, 2022.

Type 2 diabetes predicted effector genes

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• Type 2 diabetes

Method

Candidate effector gene predictions were generated by Bayesian colocalization of T2D GWAS signals and eQTLs in T2D-relevant tissues.

CARDIoGRAMplusC4D CAD predicted effector genes

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• Coronary artery disease

Method

These coronary artery disease (CAD) effector gene predictions from the CARDIoGRAMplusC4D consortium considered 8 locus-based or similarity-based predictors at each of 239 genome-wide significant CAD loci.

Stroke predicted effector genes

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• Stroke

Method

Potential effector genes were prioritized, using multiple evidence sources, at loci genetically associated with stroke risk.

Blood pressure predicted effector genes

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• Blood pressure

Method

Genes were prioritized at blood pressure-associated loci by combining several types of evidence:

Obesity predicted effector genes

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• Obesity

Method

Variants located in obesity-associated GWAS loci were tested for cell type specific or cross-tissue enhancer modulating properties using a massively parallel reporter assay.