UK10K BMD GWAS

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Publications

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Zheng H-F, et al.
Nature. 2015 Oct 1;526(7571):112-7. doi: 10.1038/nature14878.
PMID:26367794

Phenotypes

  • femoral neck bone mineral density
  • forearm bone mineral density
  • lumbar spine bone mineral density

Subjects

Subjects Cohort Ancestry Genotyping method
1,356 ALSPAC European whole genome sequence
1,512 Twins UK European whole genome sequence
807 AOGC European whole exome sequence
708 FHS European whole exome sequence
218 RS‐I European whole exome sequence
587 ESP European whole exome sequence
1,227 ERF European whole exome sequence
2,029 ALSPAC European genome-wide genotyped
1,859 AOGC European genome-wide genotyped
6,388 FHS European genome-wide genotyped
4,581 MrOS European genome-wide genotyped
5,122 RS‐I European genome-wide genotyped
3,322 SOF European genome-wide genotyped
3,019 Twins UK European genome-wide genotyped

Project

Genetic Factors for Osteoporosis (GEFOS) Consortium Learn more >

 

Experiment summary

This study is a meta-analysis of genetic associations for bone mineral density measured at the femoral neck, forearm, and lumbar spine. Samples were subjected to whole-genome sequencing, whole-exome sequencing, or genotyping and imputation to the Uk10K/1000Genomes reference panel.

contributing community
msk, mskkp, bone
Dataset ID
GWAS_GEFOS-UK10KBMD_eu