Publications
The Hoorn Diabetes Care System (DCS) cohort. A prospective cohort of persons with type 2 diabetes treated in primary care in the Netherlands.
van den Hiejden AA, et al.
BMJ Open. 2017 Jun 6;7(5):e015599. doi: 10.1136/bmjopen-2016-015599
Dataset phenotypes
- fasting glucose
- BMI
- total cholesterol
- serum creatinine
- diastolic blood pressure
- eGFR-creat (serum creatinine)
- HbA1c
- HbA1c (mmol/L)
- heart rate
- height
- HDL cholesterol
- LDL cholesterol
- systolic blood pressure
- triglycerides
- urinary albumin
- urinary albumin-to-creatinine ratio
- urinary creatinine
- weight
Dataset subjects
| Cases | Controls | Cohort (Click to view selection criteria for cases and controls) | Ancestry |
|---|---|---|---|
| 1,997 | 0 | Hoorn Diabetes Care System cohort | European |
Project
The Hoorn Studies project is a prospective study based in the West Friesland region of the Netherlands that aims to determine the factors influencing the incidence and progression of type 2 diabetes.
Experiment summary
The Hoorn Diabetes Care System cohort consists of type 2 diabetics for whom clinical measurements are taken annually. Samples were genotyped using the Illumina HumanCoreExome chip array and imputed to HRC reference via the Michigan imputation server. Phenotypes were normalised using inverse rank-based normalisation on the residuals of a linear model adjusting for age, sex, and 4 Principal Components. The top 10 Principal Components were used as covariates in this analysis.
In the Hoorn DCS 2019 dataset, phenotypes were measured across multiple timepoints (annual visits) for each patient. Associations displayed in the Portal currently represent only the first timepoint.