Type 2 diabetes subtypes 2021 GWAS: European ancestry

Summary statistics are available for download from the GWAS Catalog.

Publications

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes.
Mansour Aly D, et al.
Nat Genet. 2021 Nov;53(11):1534-1542. doi: 10.1038/s41588-021-00948-2. Epub 2021 Nov 4.
PMID: 34737425

Phenotypes

  • Type 2 diabetes
  • Mild age-related type 2 diabetes
  • Mild obesity-related type 2 diabetes
  • Severe autoimmune type 2 diabetes
  • Severe insulin-deficient type 2 diabetes
  • Severe insulin-resistant type 2 diabetes

Experiment summary

This study analyzed genetic associations for type 2 diabetes (T2D; 9,486 cases, 2,744 controls) and its subtypes mild age-related T2D (2,861 cases, 2,744 controls), mild obesity-related T2D (1,374 cases, 2,744 controls), severe autoimmune T2D (452 cases, 2,744 controls), severe insulin-deficient T2D (1,193 cases, 2,744 controls), and severe insulin-resistant T2D (1,130 cases, 2,744 controls) in individuals of European ancestry.

Dataset ID
Mansour2021_DiabetesSubtypes_EU