GENIE 2022 DKD GWAS

Download summary statistics

CKD
Microalbuminuria
Macroalbuminuria
ESRD vs. macroalbuminuria
ESRD vs. all
ESRD
CKD extremes
CKD-DKD
All vs. control
Severe DKD

README

Publications

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.
Sandholm N, Cole JB, et al., Diabetologia. 2022 Jun 28. doi: 10.1007/s00125-022-05735-0.
PMID: 35763030

Phenotypes

• All diabetic kidney disease vs. controls
• Chronic kidney disease
• CKD and DKD
• End-stage renal disease
• End-stage renal disease vs. macroalbuminuria
• End-stage renal disease vs. no ESRD
• Extreme chronic kidney disease
• Macroalbuminuria
• Microalbuminuria
• Severe diabetic kidney disease

Experiment summary

This study, from the GEnetics of Nephropathy – an International Effort (GENIE) consortium, is a meta-analysis of genetic associations with 10 forms of diabetic kidney disease. All participants had diabetes (either T1D or T2D); cases had diabetic kidney disease while controls did not.