Lung function GWAS: SpiroMeta cohorts

Dataset

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Publications

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Shrine N, et al.
Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7

Dataset phenotypes

  • Forced expired volume in 1 second (FEV1)
  • Forced vital capacity (FVC)
  • FEV1 to FVC ratio
  • Peak expiratory flow

Dataset subjects

Subjects Cohort Ancestry
5,934 British 1958 Birth Cohort (B58C) European
4,355 Busselton Health Study 1 and 2 (BHS1&2) European
826 CROATIA-Korcula study European
493 CROATIA-Split study European
925 CROATIAVis study European
20,771 European Prospective Investigation into Cancer and Nutrition Cohort (EPIC population based) European
16,048 Generation Scotland: Scottish Family Health Study (GS:SFHS) European
821 Finnish Health 2000 survey (H2000) European
1,474 Cooperative Health Research in the Region of Augsburg (KORA F4) European
1,147 Cooperative Health Research in the Region of Augsburg (KORA S3) European
991 Lothian Birth Cohort 1936 (LBC1936) European
5,078 Northern Finland Birth Cohort of 1966 (NFBC1966) European
3,210 Northern Finland Birth Cohort of 1986 (NFBC1986) European
871 Northern Sweden Population Health Study (NSPHS) European
1,802 Orkney Complex Disease Study (ORCADES) European
806 Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) European
1,378 Swiss study on Air Pollution and Respiratory Diseases in Adults (SAPALDIA) European
1,759 Study of Health in Pomerania (SHIP) European
804 Study of Health in Pomerania (SHIP-TREND) European
7,442 UK Household Longitudinal Study (UKHLS) European
1,701 VIKING study European
419 Young Finnish Study (YFS) European

Experiment summary

This study analyzed genetic associations for 4 measures of lung function in over 79,000 subjects from SpiroMeta Consortium cohorts. 

Dataset ID
GWAS_SpiroMeta_eu_Spiro