Download summary statistics for this dataset (additive model analysis) and also for the analyses using the dominant, genotype, heterodominant, and recessive models.
Publications
The impact of non-additive genetic associations on age-related complex diseases.
Guindo-MartÃnez M, et al.
Nat Commun. 2021 Apr 23;12(1):2436. doi: 10.1038/s41467-021-21952-4.
PMID:33893285
Phenotypes
Phenotypes are defined in this document.
- Acute reaction to stress
- Age-related macular degeneration
- Allergic rhinitis
- Any cancer
- Any cardiovascular disease
- Any osteoarthritis
- Asthma
- Dermatophytosis
- Dyslipidemia
- EHR-defined osteoporosis (based on the ICD-9-CM diagnosis codes 733.x)
- Frequent insomnia symptoms
- Hemorrhoids
- Hernia abdominopelvic cavity
- Hypertension
- Irritable bowel syndrome
- Iron deficiency
- Major depressive disorder
- Peptic ulcers
- Peripheral vascular disease
- Psychiatric disorders
- Type 2 diabetes
- Varicose veins
Subjects
All subjects were individuals of European ancestry from the Kaiser Permanente Research Program on Genes, Environment and Health: A Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort.
| Phenotype | Cases | Controls |
|---|---|---|
| Acute reaction to stress | 4,314 | 52,323 |
| Age-related macular degeneration | 3,685 | 52,952 |
| Allergic rhinitis | 13,936 | 42,701 |
| Any cancer | 17,131 | 39,506 |
| Any cardiovascular disease | 15,009 | 41,628 |
| Any osteoarthritis | 20,212 | 36,425 |
| Asthma | 9,209 | 47,428 |
| Dermatophytosis | 7,676 | 48,961 |
| Dyslipidemia | 30,244 | 26,393 |
| EHR-defined osteoporosis | 5,399 | 51,238 |
| Frequent insomnia symptoms | 3,972 | 52,665 |
| Hemorrhoids | 9,129 | 47,508 |
| Hernia abdominopelvic cavity | 6,291 | 50,346 |
| Hypertension | 28,391 | 28,246 |
| Irritable bowel syndrome | 3,117 | 53,520 |
| Iron deficiency | 2,439 | 54,198 |
| Major depressive disorder | 7,264 | 49,373 |
| Peptic ulcers | 920 | 55,717 |
| Peripheral vascular disease | 4,301 | 52,336 |
| Psychiatric disorders | 8,624 | 48,013 |
| Type 2 diabetes | 6,967 | 49,670 |
| Varicose veins | 2,483 | 54,154 |
Experiment summary
This study analyzed genetic associations for 22 age-related diseases and conditions, defined in this document. In addition to applying the standard additive model association testing, the authors applied four additional models (dominant, genotypic, heterodominant, and recessive).
Summary statistics from all analyses may be downloaded at the link above.
In addition to applying the standard additive model association testing, the authors applied four additional models. Results for the additive model are presented in the Portal in the following datasets:
- GERA additive model age-related GWAS
- GERA age-related GWAS: chrX, females
- GERA age-related GWAS: chrX, males
Results for the non-additive models are presented in the Non-Additive Genetic Effects Knowledge Portal. Summary statistics from the analyses using the additive, dominant, genotype, heterodominant, and recessive models may be downloaded at the link above.