Dataset
Download summary statistic files:
mRS 0-1 vs 2-6 at 3 months
mRS 0-1 vs 2-6 at 3 months adj stroke severity
mRS 0-2 vs 3-6 at 3 months
mRS 0-2 vs 3-6 at 3 months adj stroke severity
mRS at 3 months
mRS at 3 months adj stroke severity
README
Publications
Genome-wide Association Meta-Analysis of Functional Outcome After Ischemic Stroke.
Söderholm M, et al.
Neurology. 2019 Mar 19;92(12):e1271-e1283. doi: 10.1212/WNL.0000000000007138.
PMID:30796134
Dataset phenotypes
- mRS 0-2 vs 3-6 at 3 months
- mRS 0-2 vs 3-6 at 3 months adj stroke severity
- mRS 0-1 vs 2-6 at 3 months
- mRS 0-1 vs 2-6 at 3 months adj stroke severity
- mRS at 3 months
- mRS at 3 months adj stroke severity
Dataset subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 502 | Vascular Ischemia Study (Australia) | European |
| 354 | Greater Cincinnati/ Northern Kentucky Stroke Study (Cincinnati) | European |
| 342 | Helsinki-2000 Study (Finland) | European |
| 906 | Hospital del Mar (HdM) | European |
| 458 | Leuven Stroke Genetics Study (Leuven) | European |
| 489 | Lund Stroke Register (LSR-1) | European |
| 478 | Lund Stroke Register (LSR-2) | European |
| 348 | Malmö Diet and Cancer Study (MDC) | European |
| 49 | Massachusetts General Hospital Genes Affecting Stroke Risk and Outcomes Study (MGH-GASROS) (MGH-1) | European |
| 76 | Massachusetts General Hospital Genes Affecting Stroke Risk and Outcomes Study (MGH-GASROS) (MGH-2) | European |
| 225 | Massachusetts General Hospital Genes Affecting Stroke Risk and Outcomes Study (MGH-GASROS) (MGH-3) | European |
| 453 | Oxford Stroke Study (Oxford) | European |
| 760 | Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) | European |
| 398 | Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS-RS) | European |
| 130 | Val de Hebron-1 (VdH-1) | European |
| 105 | Val de Hebron-2 (VdH-2) | European |
| 92 | Washington University Stroke Study (WashU) | European |
Project
The Genetics of Ischaemic Stroke Functional Outcome (GISCOME) network aims to identify genetic variants that may influence functional outcome after ischemic stroke.
Experiment summary
This study analyzed genetic associations with modified Rankin Scale (mRS) score, a measure of disability, at 60 to 90 days after ischemic stroke. mRS was evaluated as two dichotomous variables (score of 0–2 vs 3–6, and score of 0–1 vs 2–6) and as a continuous variable (reported as the "mRS at 3 months" phenotype). Associations were either adjusted for stroke severity, or unadjusted.