Dataset
Publications
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Jansen IE, et al.
Nat Genet. 2019 Mar;51(3):404-413. doi: 10.1038/s41588-018-0311-9
Dataset phenotypes
- Alzheimer's disease
Dataset subjects
| Cases | Controls | Cohort | Ancestry |
|---|---|---|---|
| 2,066 | 7,637 | Psychiatric Genomic Consortium-Alzheimer Workgroup: Norwegian DemGene Network | European |
| 322 | 6,325 | Psychiatric Genomic Consortium-Alzheimer Workgroup: TwinGene | European |
| 348 | 779 | Psychiatric Genomic Consortium-Alzheimer Workgroup: Swedish Twin Studies of Aging | European |
| 17,008 | 37,154 | International Genomics of Alzheimer's Project (IGAP) | European |
| 4,343 | 3163 | Alzheimer’s Disease Sequencing Project (ADSP) | European |
| 47,793 | 328,320 | UK Biobank | European |
Ancestry
Experiment summary
This dataset represents a meta-analysis of two Alzheimer’s disease (AD) association analyses. Phase 1 included 24,087 clinically diagnosed late-onset AD cases and 55,058 controls. Phase 2 included 47,793 cases of AD-by-proxy from the UK Biobank and 328,320 controls. AD-by-proxy is defined as individuals having one or two parents with AD; cases with two parents were given greater weight. AD-by-proxy controls had two parents without AD; subjects with older parents were given greater weight.
Dataset ID
GWAS_UKBiobankAD_eu