Dataset
Publications
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.
Trajanoska K, et al.
BMJ. 2018 Aug 29;362:k3225. doi: 10.1136/bmj.k3225
Dataset phenotypes
- Bone fracture
Dataset subjects
| Cases | Controls | Cohort | Ancestry |
|---|---|---|---|
| 1,458 | 1,727 | Age, Gene/Environment Susceptibility Reykjavik Study (AGES) | European |
| 685 | 1,113 | Anglo-Australasian Osteoporosis Genetics Consortium (AOGC) | European |
| 715 | 1,483 | B-vitamins for the PRevention Of Osteoporotic Fractures (BPROOF) | European |
| 519 | 2,742 | Cardiovascular Health Study (CHS) | European |
| 1,836 | 14,560 | DeCODE Genetics Study (DeCODE) | European |
| 217 | 4,296 | Estonian Genome Center University of Tartu-I (EGCUT-I) | European |
| 71 | 1,717 | Estonian Genome Center University of Tartu-II (EGCUT-II) | European |
| 2,926 | 17,710 | European Prospective Investigation into Cancer, Norfolk study (EPICNOR) | European |
| 260 | 1,342 | Erasmus Rucphen Family (ERF) | European |
| 1,520 | 2,782 | Framingham Heart Study (FHS) | European |
| 273 | 597 | Gothenburg Osteoporosis and Obesity Determinants Study (GOOD) | European |
| 308 | 1,353 | Health Aging and Body Composition (HABC) | European |
| 79 | 627 | Hong Kong Osteoporosis Study (HKOS) | East Asian |
| 918 | 3,555 | Osteoporotic Fractures in Men (MrOS) | European |
| 426 | 4,816 | The PROpective Study of Pravastatin in the Elderly at Risk (PROSPER) | European |
| 2,163 | 3,574 | Rotterdam Study I (RS I) | European |
| 932 | 1,220 | Rotterdam Study II (RS II) | European |
| 505 | 2,421 | Rotterdam Study III (RS III) | European |
| 1,611 | 1,698 | Study of Osteoporotic Fractures (SOF) | European |
| 839 | 4,111 | TwinsUK (TUK123) | European |
| 14,492 | 130,563 | UK Biobank (UKBB) | European |
| 1,832 | 20,498 | Women's Genome Health Study (WGHS) | European |
| 1,058 | 647 | Women's Health Initiative Clinical Trial (WHICT) | European |
| 1,603 | 989 | Women's Health Initiative Observational Study (WHIOS) | European |
| 611 | 975 | CV risk in Young Finns Study (YFS) | European |
Project
Genetic Factors for Osteoporosis (GEFOS) Consortium Learn more >
Experiment summary
This study was a large-scale GWAS meta-analysis for genetic associations with bone fracture in 25 cohorts from Europe, United States, east Asia, and Australia.
Accessing GEFOS Any-type of Fracture GWAS results
GEFOS Any-type of Fracture GWAS results are available at these locations:
- On Gene Pages in the Top variants and High-impact variants tables and in LocusZoom static plots, for the Fracture phenotype
- On Variant Pages in the Associations at a glance section, the Associations across all datasets table, and in LocusZoom static plots
- Via the Variant Finder tool
- From the Explore by phenotype search on the home page: first select the Fracture phenotype and then on the resulting page, select the GEFOS Any-type of Fracture GWAS dataset.
Dataset ID
GWAS_GEFOS