Dataset
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Publications
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Prins BP, et al.
Dataset phenotypes
- QRS interval duration
Dataset subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 2,118 | Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) | European |
| 9,606 | The Atherosclerosis Risk in Communities Study (ARIC) | European |
| 846 | British Genetics of Hypertension (BRIGHT) | European |
| 3,088 | Cardiovascular Health Study (CHS) | European |
| 955 | Erasmus Rucphen Family Study (ERF) | European |
| 7,046 | Framingham Heart Study (FHS) | European |
| 9,089 | Generation Scotland: Scottish Family Health Study (GS) | European |
| 251 | Genetics of Cerebral Hemorrhage with Anticoagulation (GOCHA) | European |
| 1,757 | The Genetic Regulation of Arterial Pressure of Humans in the Community (GRAPHIC) | European |
| 5,763 | INTER99 | European |
| 2,582 | Cooperative Health Research in the Region Augsburg (KORA) | European |
| 322 | CROATIA-Korcula (KORCULA) | European |
| 1,903 | The LifeLines Cohort Study (LifeLines) | European |
| 5,617 | The Netherlands Epidemiology of Obesity (NEO) | European |
| 2,459 | Massachusetts General Hospital Cardiology and Metabolic Cohort (CAMP) | European |
| 2,254 | Rotterdam Study 1 (RS-1) | European |
| 6,314 | SHIP-o/SHIP-Trend (SHIP) | European |
| 469 | TwinsUK Registry (TwinsUK) | European |
| 1,698 | Utrecht Health Project (UHP) | European |
| 11,936 | Women’s Health Initiative (WHI) | European |
| 1,831 | Young Finns Study (YFS) | European |
Project
The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies.
Experiment summary
Length of the QRS interval on an electrocardiogram (ECG) is a measure of the duration of ventricular depolarization in the heart, and a prolonged QRS interval predicts an increased risk of death. This study surveyed QRS interval associations in 77,898 participants of European ancestry and 7,695 of African descent participating in the CHARGE consortium.