Dataset
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Publications
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Prins BP, et al.
Genome Biol. 2018 Jul 17;19(1):87. doi: 10.1186/s13059-018-1457-6
Dataset phenotypes
- QRS interval duration
Dataset subjects
| 3,282 | The Atherosclerosis Risk in Communities Study (ARIC) | African American |
| 590 | Cardiovascular Health Study (CHS) | African American |
| 2,193 | Jackson Heart Study (JHS) | African American |
| 1,630 | Women’s Health Initiative (WHI) | African American |
Project
The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies.
Experiment summary
Length of the QRS interval on an electrocardiogram (ECG) is a measure of the duration of ventricular depolarization in the heart, and a prolonged QRS interval predicts an increased risk of death. This study surveyed QRS interval associations in 77,898 participants of European ancestry and 7,695 of African descent participating in the CHARGE consortium.