Dataset
Download summary statistics for T2D meta-analysis
Download summary statistics for bivariate analysis
Publications
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
Zhao, W, et al.
Nat Genet. 2017 Oct;49(10):1450-1457. doi: 10.1038/ng.3943
Dataset phenotypes
- Coronary artery disease
- Type 2 diabetes
- Coronary artery disease in type 2 diabetes
- Coronary artery disease in subjects without diabetes
Dataset subjects
Discovery cohorts
| T2D Cases |
T2D Controls |
Cohort(Click to view selection criteria for cases and controls) |
Ancestry |
| 250 |
2,189 |
BRAVE
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
South Asian |
| 612 |
2,039 |
EPIDREAM
| Case selection criteria |
Control selection criteria |
| Fasting plasma glucose ≥ 7.0 mmol/L or 2-h glucose ≥ 11.1 mmol/L |
Normal fasting plasma glucose or normal 2-h glucose levels |
|
South Asian |
| 1,563 |
7,553 |
FINRISK
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
European |
| 1,418 |
5,722 |
MDC
| Case selection criteria |
Control selection criteria |
| Physician diagnosis or treatment, a fasting plasma glucose level of ≥ 7.0mmol/L, or 2-hour post glucose load level of ≥ 11.1mmol/L, on more than one occasion with symptoms of diabetes |
Controls with no prior history of diabetes and normal glucose tolerance (fasting glucose < 6mmol/L, post glucose < 7.8mmol/L |
|
European |
| 612 |
2,039 |
Medstar
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
European |
| 278 |
1,113 |
PennCATH
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
European |
| 737 |
1,804 |
PROMIS1
| Case selection criteria |
Control selection criteria |
| HbA1c > 6.5 or Fasting glucose > 125 |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis, normal HbA1c or fasting glucose levels |
|
South Asian |
| 3,930 |
3,250 |
PROMIS2
| Case selection criteria |
Control selection criteria |
| HbA1c > 6.5 or Fasting glucose > 125 |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis, normal HbA1c or fasting glucose levels |
|
South Asian |
| 2,439 |
7,078 |
PROMIS3
| Case selection criteria |
Control selection criteria |
| HbA1c > 6.5 or Fasting glucose > 125 |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis, normal HbA1c or fasting glucose levels |
|
South Asian |
| 602 |
598 |
RACE1
| Case selection criteria |
Control selection criteria |
| HbA1c > 6.5 or Fasting glucose > 125 |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis, normal HbA1c or fasting glucose levels |
|
South Asian |
| 1,084 |
1,527 |
RACE2
| Case selection criteria |
Control selection criteria |
| HbA1c > 6.5 or Fasting glucose > 125 |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis, normal HbA1c or fasting glucose levels |
|
South Asian |
Combined discovery analysis was performed on the cohorts listed above plus published data from the DIAGRAM consortium on an additional 34,840 T2D cases and 114,981 controls.
Replication cohorts
| T2D Cases |
T2D Controls |
Cohort(Click to view selection criteria for cases and controls) |
Ancestry |
| 9,817 |
6,763 |
Biobank Japan 1
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
East Asian |
| 5,646 |
19,420 |
Biobank Japan 2
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
East Asian |
| 132 |
445 |
BioMe1
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
European |
| 255 |
1,647 |
BioMe2
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, self-report, or medication usage |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis |
|
European |
| 1,778 |
4,769 |
LOLIPOP 610
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, history of diabetes, on treatment, or fasting glucose ≥ 7.0mmol/L; |
No history of T2D, and fasting glucose < 7mmol/L |
|
South Asian |
| 434 |
1,686 |
LOLIPOP 317
| Case selection criteria |
Control selection criteria |
| Physician diagnosis, history of diabetes, on treatment, or fasting glucose ≥ 7.0mmol/L; |
No history of T2D, and fasting glucose < 7mmol/L |
|
South Asian |
| 1,387 |
1,732 |
SDS
| Case selection criteria |
Control selection criteria |
| Physician diagnosis or treatment, a fasting plasma glucose level of ≥ 7.0mmol/L, or 2-hour post glucose load level of ≥ 11.1mmol/L, on more than one occasion with symptoms of diabetes |
Controls with no prior history of diabetes and normal glucose tolerance (fasting glucose < 6mmol/L, post glucose < 7.8mmol/L |
|
South Asian |
| 977 |
1,169 |
SINDI
| Case selection criteria |
Control selection criteria |
| History of T2D and HbA1c > 6.5 |
No history of T2D and HbA1c < 6.5 |
|
South Asian |
| 4,535 |
4,800 |
TAICHI
| Case selection criteria |
Control selection criteria |
| HbA1c > 6.5 or Fasting glucose > 125 |
No self report, no prior history of use of glucose lowering medication, no prior medical diagnosis, normal HbA1c or fasting glucose levels |
|
East Asian |
Experiment summary
This study was a multi-ancestry analysis of T2D risk associations followed by testing of sentinel T2D variants for association with risk of coronary heart disease.
