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Publications
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
SIGMA Type 2 Diabetes Consortium, et al.
Nature. 2014 Feb 6;506(7486):97-101. doi: 10.1038/nature12828
Phenotypes
Subjects
| Cases |
Controls |
Cohort |
Ancestry |
| 815 |
1138 |
UNAM/INCMNSZ Diabetes Study (UIDS)
| Case selection criteria |
Control selection criteria |
- ADA criteria: fasting plasma glucose values ≥126 mg/dL, current treatment with a hypoglycemic agent, or casual glucose values ≥200 mg/dL
|
- Age ≥45 years
- fasting plasma glucose concentration < 100 mg/dl
- no previous history of hyperglycemia, gestational diabetes or use of metformin
|
|
Latino |
| 690 |
472 |
Diabetes in Mexico Study (DMS)
| Case selection criteria |
Control selection criteria |
- Age ≥18 years
- previous T2D diagnosis or fasting glucose levels above 125 mg/dL
- excluded individuals with fasting glycemia between 100-125 mg/dL
|
- Age ≥45 years
- fasting glucose levels below 100 mg/dL
|
|
Latino |
| 287 |
613 |
Mexico City Diabetes Study (MCDS)
| Case selection criteria |
Control selection criteria |
- age 35-64 years
- non-pregnant females
- T2D diagnosis and medication OR ADA criteria: Fasting glucose 126 mg/dL or more or 2 hr post 75 gr of glucose load 200 or more
|
- age 35-64 years
- non-pregnant females
|
|
Latino |
| 2056 |
2143 |
Multiethnic Cohort (MEC)
| Case selection criteria |
Control selection criteria |
- self-report of T2D diagnosis or medication
- absence of T1D diagnosis
|
- no self-report of T2D diagnosis or medication
- no T1D or T2D diagnosis from the OSHPD, HMSA or KPH registries
|
|
Latino |
| Total: 3,848 |
Total: 4,366 |
|
|
Project
Slim Initiative in Genomic Medicine for the Americas (SIGMA) Learn more >
The SIGMA partnership aims to understand the genomic basis of type 2 diabetes in Mexican and Latin American populations.
