Download URL: https://www.magicinvestigators.org/downloads/
Publications
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
Wheeler E, et al.
PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383
Phenotypes
- HbA1c
Subjects
| Samples | Cohort (Click to view exclusion criteria) | Ancestry |
|---|---|---|
| 464 | AASC | East Asian |
| 323 | CAGE | East Asian |
| 7,509 | KARE | East Asian |
| 2,514 | The Nutrition and Health of Aging Population in China (NHAPC) | East Asian |
| 457 | Singapore Chinese Health Study-Coronary Heart Disease (cases) | East Asian |
| 1,024 | Singapore Chinese Health Study-Coronary Heart Disease (controls) | East Asian |
| 1,664 | Singapore Chinese Eye Study (SCES) | East Asian |
| 2,003 | Singapore Malay Eye Study (SiMES) | East Asian |
| 805 | Singapore Prospective Study Program (SP2-1M) | East Asian |
| 291 | Singapore Prospective Study Program (SP2-550) | East Asian |
| 858 | Singapore Prospective Study Program (SP2-610) | East Asian |
| 920 | TWSC | East Asian |
| 2,366 | Taichi | East Asian |
Project
MAGIC (the Meta-Analyses of Glucose and Insulin-related traits Consortium) represents a collaborative effort to combine data from multiple GWAS to identify additional loci that impact on glycemic and metabolic traits.
Experiment summary
This study is an ancestry-specific and transethnic genome-wide meta-analysis of associations with HbA1c in individuals from 82 cohorts of European, African American, East Asian, and South Asian (N=8,874) ancestry. HbA1c trait values are untransformed and adjusted for age, sex and study-specific covariates.