Download URL: https://www.magicinvestigators.org/downloads/
Publications
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
Wheeler E, et al.
PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383
Phenotypes
- HbA1c
Dataset subjects
| Samples | Cohort (Click to view exclusion criteria) | Ancestry |
|---|---|---|
| 1,854 | ARIC | African American |
| 368 | Mount Sinai BioMe Biobank (BioMe) | African American |
| 540 | CARDIA | African American |
| 615 | HABC | African American |
| 794 | HANDLS | African American |
| 1,685 | JHS | African American |
| 1,186 | MESA | African American |
| 173 | SIGNET | African American |
| 350 | WGHS | African American |
Project
MAGIC (the Meta-Analyses of Glucose and Insulin-related traits Consortium) represents a collaborative effort to combine data from multiple GWAS to identify additional loci that impact on glycemic and metabolic traits.
Experiment summary
This study is an ancestry-specific and transethnic genome-wide meta-analysis of associations with HbA1c in individuals from 82 cohorts of European, African American, East Asian, and South Asian (N=8,874) ancestry. HbA1c trait values are untransformed and adjusted for age, sex and study-specific covariates.