GWAS summary statistics | Rare variant analysis summary statistics
Publication
The impact of common and rare genetic variants on bradyarrhythmia development.
Weng L-C, Rämö JT, Jurgens SJ, Khurshid S, Chaffin M, Hall AW, et al.
Nature Genetics. 2025 Jan;57(1):53–64. doi: 10.1038/s41588-024-01978-2.
PMID: 39747593
Phenotypes
- Sinus node dysfunction (restrictive)
- Sinus node dysfunction (inclusive)
- Distal conduction disease (restrictive)
- Distal conduction disease (inclusive)
- Pacemaker implantation
Experiment summary
This study performed common-variant GWAS and rare variant analysis in up to ~1.3 million individuals of mixed ancestry to map genetic contributors to bradyarrhythmias, identifying multiple loci and implicating pathways such as ion channels, cardiac development, and sarcomeric structure; rare-variant signals highlighted genes including LMNA, SCN5A, TTN, MYBPC3, and SMAD6.
Dataset ID
Weng2024_Brady_Mixed