Publication
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.
Rahman MS, Winsvold BS, Chavez Chavez SO, et al.
Annals of the Rheumatic Diseases. 2021 Sep;80(9):1227–1235. doi: 10.1136/annrheumdis-2020-219624.
PMID: 33926923
Phenotypes
- Chronic widespread musculoskeletal pain (CWP)
Experiment summary
This GWAS analyzed 6,914 CWP cases and 242,929 controls in UK Biobank. Three loci were identified (RNF123, ATP2C1, COMT); RNF123 replicated, ATP2C1 showed suggestive evidence, and COMT did not replicate. Tissue specificity and colocalization analyses highlighted skeletal muscle relevance.
Dataset ID
Rahman2021_Chronic_Widespead_MSK_Pain_EU