Publication
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.
Guintivano J, Byrne EM, Kiewa J, Yao S, et al.
American Journal of Psychiatry. 2023 Dec 1;180(12):884-895. doi: 10.1176/appi.ajp.20230053.
PMID: 37849304
Phenotypes
- Postpartum depression (PPD)
Experiment summary
This study performed a trans-ancestry meta-analysis of GWAS for postpartum depression across European, East Asian, and African cohorts (totaling ~18,770 cases and ~58,461 controls). While no genome-wide significant loci were identified, the analysis estimated SNP-heritability (~0.14) and reported significant genetic correlations with related psychiatric and reproductive traits; cell-type enrichment highlighted inhibitory and cholinergic neuronal populations.
Dataset ID
Guintivano2023_PPD_Mixed