Summary statistics are available for download from the GWAS Catalog.
Publication
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.
DeForest N, Wang Y, Zhu Z, Dron JS, Koesterer R, Natarajan P, Flannick J, Amariuta T, Peloso GM, Majithia AR, et al.
Nature Communications. 2024 Sep 14;15(1):8068. doi: 10.1038/s41467-024-52105-y.
PMID: 39277575
Phenotypes
- Triglycerides-to-HDL cholesterol ratio (TG/HDL), proxy for insulin resistance
Experiment summary
This study conducted a genome-wide association analysis of TG/HDL ratio in 176117 males of mixed ancestry as a surrogate for insulin resistance and performed integrative genomic characterization to identify and interpret associated loci.
Dataset ID
DeForest2024_TGtoHDL_Mixed_Males