CKDGen 2024 kidney function X chromosome-wide association study: trans-ancestry, females

Summary statistics are available for download from the CKDGen consortium.

Publications

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
Scholz M et al.
Nat Commun. 2024 Jan 18;15(1):586. doi: 10.1038/s41467-024-44709-1.
PMID: 38233393

Phenotypes

  • Blood urea nitrogen
  • Chronic kidney disease (CKD)
  • eGFRcreat (serum creatinine)
  • Gout
  • Macroalbuminuria vs. controls
  • Uric acid
  • Urinary albumin-to-creatinine ratio (UACR)

Experiment summary

This study was a trans-ancestry meta-analysis of X chromosome genetic associations for kidney function traits in up to 485,086 female individuals. Note that the study did not control for diabetes status and some subjects had diabetes.

Dataset ID
Scholz2024_KidneyFunction_Mixed_Females