Complement system 2021 GWAS: European ancestry

Summary statistics are available for download from the GWAS Catalog.

Publications

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration .
Lorés-Motta L, et al.
Am J Hum Genet. 2021 Aug 5;108(8):1367-1384. doi: 10.1016/j.ajhg.2021.06.002.
PMID: 34260947

Phenotypes

• Complement factor H levels
• Complement factor H-related protein 1 levels
• Complement factor H-related protein 2 levels
• Complement factor H-related protein 3 levels
• Complement factor H-related protein 4A levels
• Complement factor H-related protein 5 levels

Experiment summary

This study analyzed genetic associations for complement factor H and related protein levels in up to 416 individuals of European ancestry.