Publications
Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.
Cade BE, et al.
Genome Med. 2021 Aug 26;13(1):136. doi: 10.1186/s13073-021-00917-8..
PMID:34446064
Phenotypes
- Apnea-Hypopnea Index
- Average oxyhemoglobin desaturation per hypopnea event
- Minimum oxyhemoglobin saturation during sleep
- Percentage of sleep with oxyhemoglobin saturation under 90%
- Average oxyhemoglobin saturation during sleep
Project
The NHLBI Trans-Omics for Precision Medicine program (TOPMed) integrates whole-genome sequencing with other 'omics data to improve scientific understanding of heart, lung, blood, and sleep disorders.
Experiment summary
This study analyzed genetic associations with five sleep-disordered breathing phenotypes in individuals of African American, Asian American, European American/Australian, and Hispanic American ancestry. Included in the analysis were whole-genome sequence data from 7,988 individuals and imputed genotype data from 13,257 individuals.
This dataset is comprised of genetic associations in females of European ancestry. The main analysis and the following subsets are also available in the Portal: