Publications
Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.
Cade BE, et al.
Genome Med. 2021 Aug 26;13(1):136. doi: 10.1186/s13073-021-00917-8..
PMID:34446064
Phenotypes
- Apnea-Hypopnea Index
- Average oxyhemoglobin desaturation per hypopnea event
- Minimum oxyhemoglobin saturation during sleep
- Percentage of sleep with oxyhemoglobin saturation under 90%
- Average oxyhemoglobin saturation during sleep
Project
The NHLBI Trans-Omics for Precision Medicine program (TOPMed) integrates whole-genome sequencing with other 'omics data to improve scientific understanding of heart, lung, blood, and sleep disorders.
Experiment summary
This study analyzed genetic associations with five sleep-disordered breathing phenotypes in individuals of African American, Asian American, European American/Australian, and Hispanic American ancestry. Included in the analysis were whole-genome sequence data from 7,988 individuals and imputed genotype data from 13,257 individuals.
In addition to the main analysis, the following subsets are available in the Portal: