Genetics of Osteoarthritis (GO) Consortium early-onset osteoarthritis GWAS

Download summary statistics (see file descriptions in the README):

KP.Format.ThumbOA.gwama.plotting.gz.minus9sout.gz
KP.Format.TKR.gwama.plotting.gz.minus9sout.gz
KP.Format.TJR.gwama.plotting.gz.minus9sout.gz
KP.Format.THR.gwama.plotting.gz.minus9sout.gz
KP.Format.SpineOA.gwama.plotting.gz.minus9sout.gz
KP.Format.KneeOA.gwama.plotting.gz.minus9sout.gz
KP.Format.KneeHipOA.gwama.plotting.gz.minus9sout.gz
KP.Format.HipOA.gwama.plotting.gz.minus9sout.gz
KP.Format.HandOA.gwama.plotting.gz.minus9sout.gz
KP.Format.GO.RAW.final.meta.results.Early_AllOA.txt.gz
KP.Format.GO.FILTER.GW.ThumbOA.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.TKR.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.TJR.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.THR.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.SpineOA.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.KneeOA.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.KneeHipOA.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.HipOA.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.HandOA.FULL.09052019.txt.gz
KP.Format.GO.FILTER.GW.AllOA.FULL.09052019.txt.gz
KP.Format.FingerOA.gwama.plotting.gz.minus9sout.gz
KP.Format.AllOA.gwama.plotting.gz.minus9sout.gz

README

Summary statistics and README for all samples except UK Biobank participants (all phenotypes)

Publications

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.
Boer CG, et al.
Cell. 2021 Nov 24;184(24):6003-6005. doi: 10.1016/j.cell.2021.11.003
PMID: 34450027

Phenotypes

  • Early-onset osteoarthritis

Project

The Genetics of Osteoarthritis (GO) Consortium is a global collaboration between all available studies with the aim of understanding the genetics of ostoarthritis and related traits.

 

Experiment summary

This study is a meta-analysis of early-onset osteoarthritis (defined as age at onset younger than 45 years) across 3 cohorts (Estonian Biobank, HUNT & UK-Biobank) that had age at onset information available. Companion datasets in the Portal from the same publication include the main analysis, Genetics of Osteoarthritis (GO) Consortium GWAS, and Genetics of Osteoarthritis (GO) Consortium GWAS, sex-specific analysis.

Dataset ID
Boer2021_EarlyOA_Mixed