Publications
Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.
Sharma A, et al.
J Autoimmun. 2018 May;89:90-100. doi: 10.1016/j.jaut.2017.12.008.
PMID:29310926
Phenotypes
- Type 1 diabetes
Experiment summary
This study is an analysis of genetic associations for progression to type 1 diabetes in a population of children who had one of nine selected HLA genotypes associated with increased risk for T1D.
Project
The Environmental Determinants of Diabetes in the Young (TEDDY) study is an international prospective study that enrolled newborn children during 5 years into a 15-year follow-up with a coordinated protocol. The TEDDY study attempts to identify the interplay between environmental factors and genetic susceptibility. The primary outcome of TEDDY is the development of persistent confirmed islet autoimmunity that is assessed every 3 months, and the secondary outcome is the diagnosis of T1D as defined by the American Diabetes Association.