Summary statistics are available for download from the GWAS Catalog.
Publications
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.
Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, et al.
Nat Commun. 2021 Jan 28;12(1):654. doi: 10.1038/s41467-021-20918-w.
PMID:33510174
Phenotypes
- Low hand grip strength (EWGSOP definition)
- Low hand grip strength (FNIH definition)
Experiment summary
This study is a meta-analysis of genetic associations with muscle weakness, defined as low hand grip strength, in males of European ancestry aged 60 and older. Two definitions of hand grip strength were analyzed: the European Working Group on Sarcopenia in Older People (EWGSOP) definition (grip strength <30 kg for males and <20 kg for females) and the Foundations of the National Institutes of Health (FNIH) definition (<26 kg for males and <16 kg for females).
This dataset is a subset of the Muscle weakness GWAS dataset.