The APOL1 Portal was created to facilitate sharing and secondary use of analyses and data related to APOL1 associated kidney disease in order to parallelize and accelerate discovery for this condition. It began as a companion to our recently published paper in which we analyzed the glomerular transcriptomes of 30 Black patients with focal segmental glomerulosclerosis (FSGS) enrolled in the NEPTUNE study: 16 with a high risk APOL1 genotype and 14 with a low risk APOL1 genotype. On the portal, users can browse all results as they are presented in the manuscript, dynamically interact with the data directly on the site, and freely download the complete RNA-seq dataset (along with meta-data) for unrestricted secondary analyses.
The APOL1 portal was conceptualized by the Sampson Lab and was developed by a team of scientists and software engineers at Boston Children’s Hospital and the Broad Institute. Key contributors of data to this portal include participants, investigators, and the data coordinating center from the NEPTUNE study as well as members of the Michigan Kidney Translational Medicine Core. For more information, email Matt Sampson at “Matthew dot Sampson at childrens dot harvard dot edu”.