Summary statistics are available for download at the GIANT Consortium website.
Publications
Genome-wide Meta-Analysis of 241,258 Adults Accounting for Smoking Behaviour Identifies Novel Loci for Obesity Traits.
Justice AE, et al.
Nat Commun. 2017; 8: 14977. doi: 10.1038/ncomms14977
PMID:28443625
Phenotypes
- BMI adjusted for smoking status
- Waist circumference adjusted for BMI-smoking status
- Waist-hip ratio adjusted for BMI-smoking status
Project
Genetic Investigation of ANthropometric Traits (GIANT) consortium Learn more >
GIANT is an international collaboration that seeks to identify genetic loci that modulate human body size and shape, including height and measures of obesity.
Experiment summary
This study is a meta-analysis of up to 79 studies comprising up to 241,258 individuals with HapMap II imputed genome-wide chip data and/or with genotyped MetaboChip data, aiming to determine the influence of smoking on weight and central adiposity. Genetic associations for BMI, waist circumference, and waist-hip ratio were analyzed after adjusting for smoking behavior. This dataset represents the European-ancestry subset of the GIANT 2017 smoking-adjusted GWAS dataset.