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Apnea-hypopnea index - European Americans
Apnea-hypopnea index in NREM sleep - European Americans
Apnea-hypopnea index in REM sleep - European Americans
Publications
Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.
Chen H, et al.
Am J Respir Cell Mol Biol. 2018 Mar;58(3):391-401. doi: 10.1165/rcmb.2017-0237OC
Phenotypes
- Apnea-Hypopnea Index
- Apnea-Hypopnea Index in REM sleep
- Apnea-Hypopnea Index in NREM sleep
Subjects
| Samples | Cohort | Ancestry |
|---|---|---|
| 1,463 | Atherosclerosis Risk in Communities Study (ARIC) | European |
| 702 | Cleveland Family Study (CFS) | European |
| 646 | Framingham Heart Study (Framingham) | European |
| 707 | Multi-Ethnic Study of Atherosclerosis (MESA) | European |
| 782 | Starr County Health Studies (Starr) | European |
| 2,209 | Osteoporotic Fractures in Men Study (MrOS) | European |
Experiment summary
This dataset represents the European-ancestry subset of the Obstructive sleep apnea GWAS dataset.
This study determined genetic associations with the Apnea-Hypopnea Index (AHI), a count of the number of total (apnea) and partial (hypopnea) breathing pauses per hour. Hypopnea was defined as having 3% or greater oxyhemoglobin desaturation. All phenotypes were rank-normalized, adjusting for age, age2, sex, age x sex, BMI, and BMI2. Mixed linear models (GEMMA) were used and were adjusted for genomic-control at a cohort level before running METAL.