Publications
Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program.
DiCorpo D, Gaynor SM, et al.
Commun Biol. 2022 Jul 28;5(1):756. doi: 10.1038/s42003-022-03702-4.
PMID: 35902682
Phenotypes
- Fasting insulin adj BMI
Subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 898 | Genetics of Cardiometabolic Health in the Amish (Amish) | European |
| 2,712 | Atherosclerosis Risk in Communities Study VTE cohort (ARIC) | Mixed |
| 424 | Cleveland Clinic Atrial Fibrillation Study (CFS) | Mixed |
| 59 | Cardiovascular Health Study (CHS) | European |
| 2,730 | Framingham Heart Study (FHS) | European |
| 449 | Genetic Studies of Atherosclerosis Risk (GeneSTAR) | Mixed |
| 806 | Genetic Epidemiology Network of Arteriopathy (GENOA) | African |
| 806 | Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) | European |
| 1,347 | Hypertension Genetic Epidemiology Network (HyperGEN) | African |
| 2,310 | Jackson Heart Study (JHS) | African |
| 3,648 | Multi-Ethnic Study of Atherosclerosis (MESA) | Mixed |
| 660 | Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk - San Antonio Family Studies (SAFS) | Hispanic |
| 914 | Samoan Adiposity Study (Samoan) | Samoan |
| 5,449 | Women's Health Initiative (WHI) | Mixed |
Project
The NHLBI Trans-Omics for Precision Medicine program (TOPMed) integrates whole-genome sequencing with other 'omics data to improve scientific understanding of heart, lung, blood, and sleep disorders.
Experiment summary
This study is part of the TOPMed project "Whole Genome Sequence Analysis of Fasting Glucose and Insulin in Individuals without Diabetes". Whole genome sequencing single variant analysis and rare variant analysis of fasting insulin was performed in 26,807 TOPMed participants.
Acknowledgments
The Analysis Commons was funded by R01HL131136. Whole genome sequencing (WGS) for the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung and Blood Institute (NHLBI). WGS was provided by the following sequencing centers: Broad Genomics (3R01HL121007-01S1); Baylor (3U54HG003273-12S2 / HHSN268201500015C); NWGC (HHSN268201600032I); Psomagen (3R01HL112064-04S1); Illumina (R01HL112064); NYGC (HHSN268201500016C). Centralized read mapping and genotype calling, along with variant quality metrics and filtering, were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1). Phenotype harmonization, data management, sample-identity QC, and general study coordination, were provided by the TOPMed Data Coordinating Center (3R01HL-120393-02S1). We gratefully acknowledge the studies and participants who provided biological samples and data for TOPMed. The contributions of the investigators of the NHLBI TOPMed Consortium are gratefully acknowledged.