ICH GWAS 2014: GOCHA cohorts

Dataset

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Both summary-level and individual-level data were generated for the ICH GWAS 2014 dataset. Individual-level data are available for the GOCHA and ISGC European Centers subjects. Summary-level data are available for the full cohort.



Data in this set may be accessed in a researcher workspace via the Data Discovery interface of the American Heart Association Institute for Precision Cardiovascular Medicine.

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Publications

Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.
Woo D, et al.
Am J Hum Genet. 2014 Apr 3;94(4):511-21. doi: 10.1016/j.ajhg.2014.02.012

Dataset phenotypes

  • all intracranial hemorrhage (All ICH)
  • non-lobar intracranial hemorrhage (Non-lobar ICH)
  • lobar intracranial hemorrhage (Lobar ICH)

Project

Genetics of Cerebral Hemorrhage on Anticoagulation (GOCHA)

PIs: Devin Brown, Jennifer Majersik, James Meschia, Jonathan Rosand, Magdy Selim, Scott Silliman, David Tirschwell, Brad Worrall.
GWAS results for 316 ICH cases (184 lobar, 132 non-lobar) and 457 ICH-free controls recruited from multiple centers across the United States. Subjects were of European ancestry and aged >55 years.

Dataset ID
GWAS_Stroke_gocha