Type 2 diabetes predicted effector genes
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Reference:
Mahajan A, McCarthy MI. Unpublished, 2019.
Method:
This heuristic considers three major types of evidence, generates a score for each, and combines the scores to result in an overall classification (for example, "Causal", "Strong", "Moderate") representing the likelihood that a gene has a role in T2D risk. Genetic evidence considers variant-level and gene-level associations, credible sets, variant impact, and experimental evidence from the literature. Regulatory evidence reflects whether a T2D- or glycemic trait-associated noncoding variant influences expression of the gene in a T2D-relevant tissue. Perturbation evidence includes evidence that the gene, or its homolog in any of several model organisms, confers phenotypes that are relevant to T2D. Find more details on the "Research Method" tab of the interface, or in this downloadable documentation.