Dataset
Publications
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Shrine N, et al.
Nat Genet. 2019 Mar;51(3):481-493. doi: 10.1038/s41588-018-0321-7
Dataset phenotypes
- Forced expired volume in 1 second (FEV1)
- Forced vital capacity (FVC)
- FEV1 to FVC ratio
- Peak expiratory flow
Dataset subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 321,047 | UK Biobank | European |
| 5,934 | British 1958 Birth Cohort (B58C) | European |
| 4,355 | Busselton Health Study 1 and 2 (BHS1&2) | European |
| 826 | CROATIA-Korcula study | European |
| 493 | CROATIA-Split study | European |
| 925 | CROATIAVis study | European |
| 20,771 | European Prospective Investigation into Cancer and Nutrition Cohort (EPIC population based) | European |
| 16,048 | Generation Scotland: Scottish Family Health Study (GS:SFHS) | European |
| 821 | Finnish Health 2000 survey (H2000) | European |
| 1,474 | Cooperative Health Research in the Region of Augsburg (KORA F4) | European |
| 1,147 | Cooperative Health Research in the Region of Augsburg (KORA S3) | European |
| 991 | Lothian Birth Cohort 1936 (LBC1936) | European |
| 5,078 | Northern Finland Birth Cohort of 1966 (NFBC1966) | European |
| 3,210 | Northern Finland Birth Cohort of 1986 (NFBC1986) | European |
| 871 | Northern Sweden Population Health Study (NSPHS) | European |
| 1,802 | Orkney Complex Disease Study (ORCADES) | European |
| 806 | Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) | European |
| 1,378 | Swiss study on Air Pollution and Respiratory Diseases in Adults (SAPALDIA) | European |
| 1,759 | Study of Health in Pomerania (SHIP) | European |
| 804 | Study of Health in Pomerania (SHIP-TREND) | European |
| 7,442 | UK Household Longitudinal Study (UKHLS) | European |
| 1,701 | VIKING study | European |
| 419 | Young Finnish Study (YFS) | European |
Experiment summary
This study analyzed genetic associations for 4 measures of lung function in over 400,000 subjects from the UK Biobank population and from SpiroMeta Consortium cohorts. Subsets are available, comprised of only the UK Biobank cohort or only the SpiroMeta cohorts.
Dataset ID
GWAS_SpiroMeta_eu