Dataset
Download gene-level association scores | README
Publications
Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.
Choi SH, Jurgens SJ, et al.
Circ Res, 126 (2), 200-209 2020 Jan 17. doi: 10.1161/CIRCRESAHA.119.315686.
PMID:31691645
Dataset phenotypes
- Atrial fibrillation
Dataset subjects
| Cases | Controls | Cohort | Ancestry |
|---|---|---|---|
| 1,546 | 41,593 | UK Biobank | White European |
Experiment summary
Exome-wide single variant association analysis for atrial fibrillation was performed for UK Biobank participants of white European ancestry for whom high-quality genotyping and exome sequencing data were available. Rare coding variants (MAF ≤ 1%) that were predicted to cause loss of function were associated with atrial fibrillation in the exome sequencing cohort using a gene-based burden analysis.
Single-variant genetic associations are integrated into the T2DKP, and the gene-level results are available for download from the Downloads pages of the T2DKP, CVDKP, and CMDKP.