Dataset
Download summary statistics for Intracerebral hemorrhage or small vessel ischemic stroke
Download summary statistics for Lobar intracerebral hemorrhage or small vessel ischemic stroke
Download summary statistics for Non-lobar intracerebral hemorrhage or small vessel ischemic stroke
Publications
Genome-wide association study of cerebral small vessel disease reveals established and novel loci.
Chung J, et al.
Brain. 2019 Oct 1;142(10):3176-3189. doi: 10.1093/brain/awz233.
PMID:31430377
Dataset phenotypes
- Intracerebral hemorrhage or small vessel ischemic stroke
- Lobar intracerebral hemorrhage or small vessel ischemic stroke
- Non-lobar intracerebral hemorrhage or small vessel ischemic stroke
Dataset subjects
| Cases | Controls | Cohort | Ancestry |
|---|---|---|---|
| 386 | 387 | GOCHA ICH GWAS | European |
| 574 | 530 | ISGC-EUR ICH GWAS | European |
| 848 | 794 | GERFHS I-III ICH GWAS | European |
| 4,453 | 233,058 | MEGASTROKE SVS GWAS | European |
Experiment summary
Within each intracerebral hemorrhage (ICH) dataset, genome-wide association analyses were performed for all ICH, lobar ICH, and non-lobar ICH. The results were combined by meta-analysis. Multi-trait analysis of GWAS (MTAG) was then applied directionally to return results for ICH boosted by the large-scale MEGASTROKE GWAS of SVS.