Publications
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
Chen P, et al.
PLoS One. 2013 Nov 7;8(11):e79767. doi: 10.1371/journal.pone.0079767
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
Sim X, et al.
PLoS Genet. 2011 Apr;7(4):e1001363. doi: 10.1371/journal.pgen.1001363
Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians.
Lavanya R, et al.
Ophthalmic Epidemiol. 2009 Nov-Dec;16(6):325-36. doi: 10.3109/09286580903144738
Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians.
Lavanya R, et al.
Ophthalmic Epidemiol. 2009 Nov-Dec;16(6):325-36. doi: 10.3109/09286580903144738
Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES).
Foong AW, et al.
Ophthalmic Epidemiol. 2007 Jan-Feb;14(1):25-35 doi: 10.1080/09286580600878844
Dataset phenotypes
Phase 1 analysis:
- type 2 diabetes
- type 2 diabetes adjusted for BMI
Dataset subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 1,811 | Diabetic Cohort (DC) - Singapore Prospective Study Program (SP2), Illumina Human 1M-Duo v3 whole genome SNP genotyping chip | East Asian |
| 2,035 | Diabetic Cohort (DC) - Singapore Prospective Study Program (SP2), Illumina Human610-Quad v1.0 DNA Analysis BeadChip | East Asian |
| 1,760 | Singapore Chinese Eye Study | East Asian (Chinese) |
| 2,363 | Singapore Malay Eye Study | East Asian (Malay) |
| 2,279 | Singapore Indian Eye Study | South Asian (Indian) |
Projects
Diabetic Cohort-Singapore Prospective Study Program (DC-SP2) Learn more >
The Diabetic Cohort (DC) is a prospective cohort that consists of 14,355 adult patients with type 2 diabetes who were recruited from various polyclinics and restructured hospitals in the period 2004 to 2010. T2D cases were selected from the Diabetic Cohort.
The Singapore Prospective Study Program (SP2) is a population-based cohort study designed to examine the pathogenesis of cardiovascular and metabolic diseases such as hypertension, dyslipidemia, obesity, and T2D in Singapore. SP2 includes 6,968 participants from one of four previous cross-sectional studies: Thyroid and Heart Study 1982–1984, National Health Survey 1992, National University of Singapore Heart Study 1993–1995 or National Health Survey 1998. Non-diabetic controls were selected from SP2.
Singapore Epidemiology of Eye Disease (SEED) Learn more >
The Singapore Epidemiology of Eye Diseases (SEED) programme aims to document the prevalence, incidence, risk factors and public health significance of eye diseases in Singapore through large-scale population-based epidemiological studies. These studies include (1) Singapore Chinese Eye Study (SCES), (2) Singapore Malay Eye Study (SiMES) and (3) Singapore Indian Eye Study (SINDI). All three studies conducted age-stratified random sampling of adults aged 40-80+ residing in the South-Western part of Singapore.
Experiment summary
Meta-analysis of type 2 diabetes associations was performed on the cohorts listed above using both BMI-unadjusted and BMI-adjusted models.
Overview of analysis and results
Data were analyzed by the Analysis Team at the Accelerating Medicines Partnership Data Coordinating Center (AMP-DCC), Broad Institute, using Loamstream software and the AMP-DCC Data Analysis Pipeline. After sample quality control (see the Quality Control report, linked below), results from the cohorts listed above were combined in meta-analysis. Results are summarized below; see the Analysis Reports (links below) for full details.
No T2D associations reached genome-wide significance in either the unadjusted or BMI-adjusted models.
Detailed reports
Genotype Data Quality Control Report (download PDF)
AMP-DCC Phase 1 Data Analysis Report (download PDF)