Publications
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
Sim X, et al.
PLoS Genet. 2011 Apr;7(4):e1001363. doi: 10.1371/journal.pgen.1001363
Dataset phenotypes
Phase 1 analysis:
- fasting insulin
- fasting insulin adjusted for BMI
Dataset subjects
| Subjects | Cohort(Click to view selection criteria for cases and controls) | Ancestry |
|---|---|---|
| 1,896 | Singapore Prospective Study Program (SP2) | East Asian |
Project
The Diabetic Cohort-Singapore Prospective Study Program (DC_SP2) is a T2D case-control study to identify genetic and environmental risk factors for diabetes in Singapore Chinese.
Acknowledgments
This study was funded through grants from the Biomedical Research Council of Singapore (BMRC) and the National Medical Research Council of Singapore (NMRC). Genome Institute of Singapore provided services for genotyping.
Experiment summary
The Singapore Prospective Study Program (SP2) is a population-based cohort study designed to examine the pathogenesis of cardiovascular and metabolic diseases such as hypertension, dyslipidemia, obesity, and T2D in Singapore. SP2 includes 6,968 participants from one of four previous cross-sectional studies: Thyroid and Heart Study 1982–1984, National Health Survey 1992, National University of Singapore Heart Study 1993–1995 or National Health Survey 1998. Non-diabetic controls were selected from SP2.
Samples were genotyped using the Illumina Human 1M-Duo v3 whole genome SNP genotyping chip or the Illumina Human610-Quad v1.0 DNA Analysis BeadChip.
Overview of analysis and results
Data were analyzed by the Analysis Team at the Accelerating Medicines Partnership Data Coordinating Center (AMP-DCC), Broad Institute, using LoamStream software and the AMP-DCC Data Analysis Pipeline. After sample quality control (see the Quality Control report, linked below), results from the two arrays were combined in meta-analysis. Results are summarized below; see the Analysis Report (below) for full details.
In the BMI-unadjusted model, two fasting insulin associations reached genome-wide significance: rs3763643 in the region of the IKBKAP gene, with a p-value of 8.86 x 10e-8, and rs1759842 in the region of the FAM206A gene, with a p-value of 9.78 x 10e-8. No fasting insulin associations reached genome-wide significance in the BMI-adjusted model.
Detailed reports
Genotype Data Quality Control Report (download PDF)
AMP-DCC Phase 1 Data Analysis Report (download PDF)