Publications
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Estrada K, et al.
Nat Genet. 2012 Apr 15;44(5):491-501. doi: 10.1038/ng.2249
Phenotypes
- Lumbar spine bone mineral density
- Femoral neck bone mineral density
Subjects
| Samples | Cohort | Ancestry |
|---|---|---|
| 918 | Amish Family Osteoporosis Study (AFOS) | European |
| 1,955 | Anglo-Australasian Osteoporosis Genetics Consortium (AOGC) | European |
| 3,291 | Cardiovascular Health Study (CHS) | European |
| 7,605 | DeCODE Genetics Study (DeCODE) | European |
| 1,602 | Erasmus Rucphen Family (ERF) | European |
| 249 | European Prospective Investigation into Cancer, Norfolk study (EPICNOR) | European |
| 3,886 | Framingham Heart Study (FHS) | European |
| 938 | Gothenburg Osteoporosis and Obesity Determinants Study (GOOD) | European |
| 1,649 | Health Aging and Body Composition (HABC) | European |
| 800 | Hong Kong Osteoporosis Study (HKOS) | East Asian |
| 1,487 | Indiana Genetics of Bone Fragility Study (Indiana) | European |
| 427 | The Orkney Complex Disease Study (ORCADES) | European |
| 5,746 | Rotterdam Study I (RS I) | European |
| 2,157 | Rotterdam Study II (RS II) | European |
| 1,212 | Rotterdam Study III (RS III) | European |
| 1,511 | TwinsUK (TUK-1) | European |
| 2,801 | TwinsUK (TUK-23) | European |
Project
Genetic Factors for Osteoporosis (GEFOS) Consortium Learn more >
Experiment summary
This study is a meta-analysis of 17 genome-wide association studies for bone mineral density (BMD) of the lumbar spine and femoral neck.
Dataset ID
GWAS_GEFOS2