Dataset
Download summary statistics:
- Associations with average oxyhemoglobin saturation during sleep (average SpO2): Download
- Associations with minimum oxyhemoglobin saturation during sleep (minimum SpO2): Download
- Associations with the percentage of sleep with SpO2 < 90% (Per90): Download
- README
Publications
Associations of Variants In the Hexokinase 1 and Interleukin 18 Receptor Regions with Oxyhemoglobin Saturation During Sleep.
Cade BE, et al.
PLoS Genet. 2019 Apr 16;15(4):e1007739. doi: 10.1371/journal.pgen.1007739
Dataset phenotypes
- average oxyhemoglobin saturation during sleep
- minimum oxyhemoglobin saturation during sleep
- percentage of sleep with oxyhemoglobin saturation under 90%
Dataset subjects
| Samples | Cohort | Ancestry |
|---|---|---|
| 1,432 | Atherosclerosis Risk in Communities Study (ARIC) | European American |
| 185 | Cardiovascular Health Study (CHS) | African American |
| 731 | Cardiovascular Health Study (CHS) | European American |
| 719 | Cleveland Family Study (CFS) | African American |
| 692 | Cleveland Family Study (CFS) | European American |
| 640 | Framingham Heart Study (Framingham) | European American |
| 11,351 | Hispanic Community Health Study/Study of Latinos (HCHS/SOL) | Hispanic American |
| 496 | Jackson Heart Study (JHS) | African American |
| 490 | Multi-Ethnic Study of Atherosclerosis (MESA) | African American |
| 228 | Multi-Ethnic Study of Atherosclerosis (MESA) | Asian American |
| 707 | Multi-Ethnic Study of Atherosclerosis (MESA) | European American |
| 458 | Multi-Ethnic Study of Atherosclerosis (MESA) | Hispanic American |
| 2,178 | Osteoporotic Fractures in Men Study (MrOS) | European American |
| 782 | Starr County Health Studies (Starr) | European American |
| 1,647 | Western Australian Sleep Health Study (WASHS) | European Australian |
Experiment summary
This study determined genetic associations with three sleep disordered breathing phenotypes: the average oxyhemoglobin saturation of an individual across an entire sleep episode, after removing artifact and measurements during wake; the single pointwise minimum oxyhemoglobin saturation using the same criteria; and the percentage of a single sleep recording where an individual has hypoxemia (defined as oxyhemoglobin saturation < 90%). All phenotypes were rank-normalized, adjusting for age, age2, sex, age x sex, BMI, and BMI2. Mixed linear models (GEMMA) were used and were adjusted for genomic-control at a cohort level before running METAL.