Cerebral WMHV GWAS 2019

Dataset

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Publications

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).
Traylor M, et al.
Neurology. 2019 Jan 18. pii: 10.1212/WNL.0000000000006952. doi: 10.1212/WNL.0000000000006952

Genome-wide meta-analysis of cerebral white matter hyperintensities in stroke.
Traylor M, et al.
Neurology. 2016 Jan 12;86(2):146-53. doi: 10.1212/WNL.0000000000002263

Dataset phenotypes

• cerebral white matter hyperintensities

Dataset subjects

Experiment summary

Cerebral white matter hyperintensities are a marker of cerebral small vessel disease, which is often a precursor to stroke. This study is a genome-side study of associations with cerebral white matter hyperintensity volume in 11,226 individuals, with the aim of identifying genetic variants significantly associated with this trait.