Summary statistics are available for download from the GWAS Catalog.
Publications
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Wood AR, et al.
Diabetes. 2017 Aug;66(8):2296-2309. doi: 10.2337/db16-1452
Phenotypes
- Acute insulin response
- Acute insulin response adj SI
- Acute insulin response adj BMI-SI
- Disposition index
- Disposition index adj BMI
- Insulin secretion rate
- Insulin secretion rate adj BMI
- Peak insulin response
- Peak insulin response adj SI
- Peak insulin response adj BMI-SI
Subjects
| Subjects | Cohort | Ancestry |
|---|---|---|
| 1,187 | BETAGENE | Hispanic |
| 617 | European Network on Functional Genomics of Type 2 Diabetes (EUGENE2) | European |
| 276 | FAMILY | European |
| 562 | Finland-United States Investigation of NIDDM Genetics (FUSION) | European |
| 1,023 | Insulin Resistance Atherosclerosis Family Study (IRASFS) | Hispanic |
| 332 | PIMA | Native American |
| 683 | Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) | European |
| 127 | Troglitazone In the Prevention Of Diabetes (TRIPOD) | Hispanic |
| 357 | YOUTH 92 | European |
| 413 | Hyperglycemic clamp cohorts (HCC) | European |
Experiment summary
This study analyzed genetic associations with first-phase insulin secretion, as measured by intravenous glucose tolerance tests in non-diabetic individuals.
Dataset ID
GWAS_IVGTT