Dataset
Publications
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Köttgen A, et al.
Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500
Dataset phenotypes
- serum urate
Dataset subjects
| Samples | Cohort | Ancestry |
|---|---|---|
| 3,219 | AGES Reykjavik Study | European |
| 1,139 | Amish Studies | European |
| 9,049 | Atherosclerosis Risk in Communities (ARIC) | European |
| 845 | Austrian Stroke Prevention Study (ASPS) | European |
| 11,520 | Australian Twin-Family Study (AUSTWIN) | European |
| 521 | Baltimore Longitudinal Study of Aging (BLSA) | European |
| 1,743 | The BRItish Genetics of HyperTension Study (BRIGHT) | European |
| 1,713 | Coronary Artery Disease Risk in Young Adults (CARDIA) | European |
| 3,252 | The Cardiovascular Health Study (CHS) | European |
| 5,409 | Cohorte Lausannoise (CoLaus) Study | European |
| 895 | CROATIA-KORCULA | European |
| 490 | CROATIA-SPLIT | European |
| 912 | CROATIA-VIS | European |
| 716 | Data from the Epidemiological Study on Insulin Resistance (DESIR) | European |
| 1,835 | European Prospective Investigation of Cancer (EPIC) Norfolk Study | European |
| 889 | Erasmus Rucphen Family Study (ERF) | European |
| 931 | Estonian Genome Center of University of Tartu (EGCUT) | European |
| 3,837 | Family Heart Study (FamHS) | European |
| 7,699 | The Framingham Heart Study (FHS) | European |
| 2,069 | Health 2000 | European |
| 1,205 | Invecchiare in Chianti (InCHIANTI) | European |
| 940 | INCIPE | European |
| 432 | INGI-Carlantino | European |
| 859 | INGI-CILENTO | European |
| 1,018 | INGI-FVG | European |
| 1,658 | INGI-Val Borbera | European |
| 1,643 | KORA F3 | European |
| 1,814 | KORA F4 | European |
| 769 | LCB1936 | European |
| 3,343 | LifeLines Cohort Study | European |
| 587 | London Life Sciences Study (LOLIPOP_EW_A) | European |
| 650 | London Life Sciences Study (LOLIPOP_EW_P) | European |
| 924 | London Life Sciences Study (LOLIPOP_EW610) | European |
| 963 | Ludwigshafen Risk and Cardiovascular Health Study (LURIC) | European |
| 1,236 | MICROS | European |
| 1,731 | Netherlands Study of Depression and Anxiety (NESDA) | European |
| 655 | NSPHS | European |
| 888 | ORCADES | European |
| 3,785 | PREVEND | European |
| 3,742 | PROCARDIS | European |
| 4,274 | RS-I | European |
| 2,123 | RS-II | European |
| 4,694 | SardiNIA Study | European |
| 4,067 | Study of Health in Pomerania (SHIP) | European |
| 1,105 | SOCCS | European |
| 896 | Sorbs | European |
| 3,640 | TwinsUK | European |
| 2,023 | Young Finns Study | European |
Experiment summary
This meta-analysis by the Global Urate Genetics Consortium (GUGC) determined associations with serum urate concentrations across 48 genome-wide association studies for 110,347 individuals of European ancestry. Elevated serum urate concentrations are linked to the risk of gout. Loci associated with decreased serum urate concentrations cluster with other loci associated with liver function and lipid metabolism to potentially identify biochemical pathways involved in a sub-type of type 2 diabetes, as described in:
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.
Udler MS, et al.
PLoS Med. 2018 Sep 21;15(9):e1002654. doi: 10.1371/journal.pmed.1002654