Summary statistics are available for download from the GWAS Catalog.
Publication
Genetic study of intrahepatic cholestasis of pregnancy in Chinese women unveils East Asian etiology linked to historic HBV epidemic.
Yang Z, et al.
Journal of Hepatology. 2025;82(5):826-835. doi: 10.1016/j.jhep.2024.11.008.
PMID: 39547589
Phenotypes
- Intrahepatic cholestasis of pregnancy (ICP)
Experiment summary
This study performed large-scale genome-wide association analyses of intrahepatic cholestasis of pregnancy in 4324 cases and 93945 controls of East Asian ancestry, with replication in independent cohorts and comparison to European datasets, identifying multiple loci including East Asian–specific signals and highlighting genes involved in bile acid physiology.
Dataset ID
Liu2024_ICP_EA