Bipolar disorder 2021 GWAS: European ancestry

Summary statistics are available for download from the GWAS Catalog.

Publication

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Mullins N, Forstner AJ, O’Connell KS, et al.
Nature Genetics. 2021 Jun;53(6):817-829. doi: 10.1038/s41588-021-00857-4.
PMID: 34002096

Phenotypes

• Bipolar disorder (BD)

Experiment summary

This genome-wide association study analyzed 41,917 bipolar disorder cases and 371,549 controls of European ancestry, identifying 64 associated loci. Risk variants were enriched in synaptic signaling pathways and genes highly expressed in neurons of the prefrontal cortex and hippocampus.